The case can be upgraded several times, allowing for more space. The inventory system features a grid system, represented by an attaché case, that has each item take up a certain number of spaces.
Los Ganados can dodge, wield melee and projectile weapons, and are capable of working collectively and communicating with each other.
The main enemies are violent villagers referred to as Los Ganados. These are often incorporated into the game's many boss fights, in which the player must avoid instant-kill attacks. There are also quick time events, in which the player must press buttons indicated on-screen to execute actions such as dodging a falling boulder or wrestling an enemy to stay alive. Based on the situation, players can interact with the environment: kicking down a ladder, jumping out of a window, dodging an attack or executing a 'finishing move' on weakened enemies. Resident Evil 4 adds context-sensitive controls.
